Author: NexaGens Technical Team. Status: published explainer, general industry information — not a claim about any specific NexaGens product. Sources: general pharmaceutical and nutraceutical delivery-system literature on liposome characterization and stability testing.
Once a product is genuinely liposomal in structure, the next question for a formulator is whether the specific claims made about it — improved dispersion, protection, association with an active — are actually supported by data. Below is a practical, non-exhaustive checklist.
Structural confirmation
Vesicle presence and morphology (cryo-TEM or freeze-fracture imaging), particle size and polydispersity index (dynamic light scattering), and lamellarity (single vs. multilamellar) should be established and, ideally, re-confirmed after reconstitution of the dry powder, since drying and rehydration can alter vesicle structure.
Active-ingredient association
The percentage of active that is genuinely encapsulated or vesicle-associated, versus free/surface active, should be quantified (for example via ultracentrifugation or dialysis separation followed by assay). A high nominal loading with a low encapsulation efficiency is a meaningfully different product than one with the same loading fully associated with the vesicle.
Stability over shelf life
Encapsulation efficiency and vesicle integrity should be tracked over the intended shelf life and under realistic storage conditions, not just at time zero. Oxidation-sensitive actives (CoQ10, curcumin, certain vitamins) in particular need light/oxygen exposure data alongside standard stability testing.
Performance claims
Any claim beyond structural and stability data — for example dispersion behaviour, in vitro release, or downstream formulation performance — should be supported by product-specific testing rather than extrapolated from the delivery-technology category in general. Comparative claims (better than X) require a like-for-like comparative study.
NexaGens publishes a Specifications tab on each product page drawn from the approved specification for that product, with the technical data sheet and the batch-specific certificate of analysis available on request — rather than publishing target or developmental figures as if they were confirmed specifications.